Figure 6

Schematic presentation of the findings. A diseased and hard wired urothelium destined to produce tumors of a given molecular subtype (green). The branching tree indicates an ongoing genomic evolution and spread of the original clone in the tumor free urothelium. Four metachronous tumors originate from different branches of the three. The tumors display omnipresent aberrations (orange) i.e., genomic aberrations present in all metachronous tumors from the same patient; shared aberrations (blue), present in some but not all metachronous tumors; private/incompatible aberrations (green), present in single metachronous tumors, i.e. aberrations that prohibit the parenthood to another metachronous tumor lacking a specific aberration. Chronology, the order at which the overt tumors appeared. The schematic image applies equally well to synchronous tumors by excluding the chronology. Scheme was created using BioRender (https://biorender.com/) and Microsoft PowerPoint 2019 (https://www.microsoft.com).