Table 1 Descriptive characteristics of 43 urothelial carcinoma of the bladder patients treated with radical cystectomy and bilateral lymphadenectomy.

From: Copy number variations in primary tumor, serum and lymph node metastasis of bladder cancer patients treated with radical cystectomy

Age (years)

Range, median

50–86, 71

Gender [n (%)]

Male

32 (74.4)

Female

11 (25.6)

Clinical tumor stage [n (%)]

cTa, cTis

2 (4.9)

cT1

6 (14.6)

cT2

32 (78.0)

cT3

1 (2.4)

Clinical tumor grade [n (%)]

cG2

4 (9.8)

cG3

37 (90.2)

Intravesical chemo- and/or immunotherapy prior to RC [n (%)]

No

33 (80.5)

Yes

8 (19.5)

Number of TURB prior to RC

Range, median

1–5, 1

Days between last TURB and RC

Range, median

7–480, 45

Pathologic tumor stage [n (%)]

pT0, pTa, pTis

1 (2.3)

pT1

3 (7.0)

pT2

17 (39.5)

pT3

12 (27.9)

pT4

10 (23.3)

Combined tumor stage [n (%)]

Localized (pT ≤ 2)

21 (48.8)

Advanced (pT3–4)

22 (51.2)

Combined disease stage [n (%)]

≤ pT2 and pN0

19 (44.2)

≥ pT3 or pN1-3

24 (55.8)

Pathologic tumor grade [n (%)]

G3

42 (97.7)

Concomitant carcinoma in situ [n (%)]

Absent

23 (53.5)

Present

20 (46.5)

Lymphovascular invasion [n (%)]

Absent

29 (67.4)

Present

14 (32.6)

Microvessel invasion [n (%)]

Absent

37 (86.0)

Present

6 (14.0)

Lymph node status [n (%)]

pN0

27 (62.8)

pN1–3

16 (37.2)

Number of lymph nodes removed

Range, median

0–44, 12

Soft tissue surgical margin status [n (%)]

Negative

35 (81.4)

Positive

8 (18.6)

Urothelial carcinoma histology [n (%)]

Pure UCB

28 (65.1)

Presence of squamous cell differentiation

7 (16.3)

Presence of non-squamous cell differentiation

8 (18.6)

Presence of incidental prostate cancer in the RC specimen [n (%)]

No

23 (53.5)

Yes

20 (46.5)

Adjuvant chemotherapy [n (%)]

Not administered

29 (67.4)

Administered

14 (32.6)

Adjuvant chemotherapy regimen [n (%)]

Cisplatin-based

6 (14.0)

Carboplatin-based

8 (18.6)