Figure 2 | Scientific Reports

Figure 2

From: Hepatobiliary malignancies have distinct peripheral myeloid-derived suppressor cell signatures and tumor myeloid cell profiles

Figure 2

Malignant tumors have a distinct myeloid cell infiltration pattern compared to benign liver lesions. (A) Representative immunohistochemistry images demonstrating infiltration of CD45+, CD33+ and HLA-DR+ cells within the liver lesions. Scale bar in bottom left represents 200 μm. (B) Quantification of intralesional CD45, CD33 and HLA-DR peak area count from HCC (n = 6), CCA (n = 10), NET (n = 4) and CRLM (n = 5) cases. Quantification of CD45, CD33 and HLA-DR peak area count from (C) lesions (n = 10 benign versus n = 21–25 malignant) and (D) adjacent normal tissue (n = 7 benign versus n = 20 malignant). Data shown as box and whiskers from min to max with median. *p < 0.05, **p < 0.01 as determined by two-way ANOVA corrected for multiple comparisons with Tukey’s test.

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