Figure 1
The expression profiles of circRNAs compared between GDM and paired adjacent control group. The Scatter-Plot (A) is a visualization method used for assessing the circRNAs expression variation (or reproducibility) between pregnant women with GDM and control group. The X and Y axis values in the scatter-Plot are the normalized signal values of the average normalized signal values (log2 scaling) of each group of samples. The green lines are Fold Change Lines. The circRNAs above the top green line and below the bottom green line indicate that the change of circRNAs in the two compared samples exceeds 2.0 fold. Volcano Plots (B): the vertical lines correspond to 2.0-fold up and down, respectively, and the horizontal line represents a p-value of 0.05 (t-test). The red point in the plot represents the differentially expressed circRNAs with statistical significance. Histogram (C): among 3678 circRNAs, a total of 2678 circRNAs were detected with 2.0-fold change and p ≤ 0.05 (t-test), of which 1532 were up-regulated and 1146 were down-regulated.
