Table 2 Biochemical Characteristics of patients of acromegaly with and without diabetes.

From: Impact of concurrent diabetes on periodontal health in patients with acromegaly

Parameters

Acromegaly with diabetes (Group A)

Acromegaly without diabetes (Group B)

Controls (Group C)

P-value

A vs. B

P-value

A vs. C

P-value

B vs. C

FPG (mg/dl)

140.5 ± 7.4

99.1 ± 2.0

98.1 ± 1.2

0.0001***

0.0001***

0.913

PPG (mg/dl)

195.9 ± 15.6

138.6 ± 7.4

–

0.061

  

HbA1c (%)

7.8 ± 0.6

5.7 ± 0.1

–

0.001***

  

GH-basal (ng/ml)

66.3 ± 16.8

64.8 ± 26.6

0.6 ± 0.2

0.998

0.008**

0.010**

IGF1 (ng/ml)

778.0 ± 101.4

802.9 ± 68.7

–

0.185

  

Nadir GH-OGTT (ng/ml)

57.2 ± 14.7

47.6 ± 17.2

–

0.978

  

Mean tumor volume (cm3)

14.5 ± 3.2

12.2 ± 4.0

–

0.375

  

TSH (μU/ml)

1.06 ± 0.1

2.0 ± 1.1

–

0.090

  

T4 (μg/dl)

6.9 ± 0.5

7.2 ± 0.5

–

0.268

  

LH (mU/ml)

2.9 ± 1.0

6.7 ± 3.2

–

0.018*

  

FSH (mU/ml)

2.6 ± 0.2

13.5 ± 7.0

–

0.002**

  

PRL (ng/ml)

27.5 ± 6.0

21.5 ± 5.1

–

0.946

  

F (nmol/l)

172.1 ± 43.4

215.5 ± 21.2

–

0.017*

  

T (nmol/l)

2.8 ± 0.5

5.2 ± 0.9

–

0.69

  

E2 (pg/ml)

4.6 ± 0.2

4.6 ± 0.2

–

0.59

  
  1. One-way ANOVA test was applied to see the comparison among Group A, B and C. Post hoc analyses for multiple comparisons were performed for significant parameters in ANOVA test. To evaluate the effect of diabetes, independent ‘t’ test for comparison of continuous parametric parameters was applied.
  2. FPG fasting plasma glucose, PPG post-prandial glucose, HbA1c glycated hemoglobin, GH growth hormone, IGF1 insulin like growth factor-1, GH-OGTT Nadir growth hormone after oral glucose tolerance test, TSH thyroid-stimulating hormone, T4 thyroxine, LH luteinizing hormone, FSH follicle stimulating hormone, PRL prolactin, T testosterone, E2 estradiol, F cortisol.
  3. Data was expressed as mean ± S.E.M, *p < 0.05, **p < 0.01, ***p < 0.001.
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