Table 4 Periodontal parameters and Serum and GCF Cytokine Levels of patients of acromegaly with and without diabetes.

From: Impact of concurrent diabetes on periodontal health in patients with acromegaly

Parameters

Acromegaly with diabetes (Group A)

Acromegaly without diabetes (Group B)

Controls (Group C)

P-value

A vs. B

P-value

A vs. C

P-value

B vs. C

Number of teeth present

27.8 ± 1.3

29.5 ± 1.1

29.8 ± 0.5

0.483

0.295

0.979

GI

1.5 ± 0.1

1.4 ± 0.1

1.5 ± 0.1

0.957

0.936

0.783

PI

1.6 ± 0.1

1.7 ± 0.1

1.5 ± 0.1

0.883

0.972

0.724

OHI-S

3.1 ± 0.3

2.8 ± 0.2

3.0 ± 0.2

0.890

0.996

0.898

GBI

51.3 ± 5.8

38.6 ± 4.5

42.9 ± 3.5

0.218

0.422

0.787

Mean PD (mm)

2.5 ± 0.2

2.2 ± 0.2

2.1 ± 0.1

0.375

0.250

0.996

Mean CAL (mm)

2.5 ± 0.6

1.3 ± 0.5

1.3 ± 0.3

0.238

0.125

0.991

Serum TGF-β1 (ng/ml)

67.9 ± 9.9

92.5 ± 13.2

58.1 ± 3.4

0.164

0.686

0.014*

Serum PDGF (pg/ml)

185.9 ± 70.4

224.2 ± 68.8

146.4 ± 28.2

0.892

0.855

0.547

Serum IL-6 (pg/ml)

16.6 ± 6

6.4 ± 1.5

6.2 ± 0.9

0.102

0.051

0.999

GCF TGF-β1 (ng/ml)

2.0 ± 0.4

1.2 ± 0.2

1.9 ± 0.1

0.094

0.862

0.379

GCF PDGF (ng/ml)

1.9 ± 0.2

2.4 ± 0.2

2.9 ± 0.3

0.756

0.090

0.379

GCF IL-6 (pg/ml)

UD

UD

UD

–

–

–

  1. One-way ANOVA test was applied to see the comparison among Group A, B and C. Post hoc analyses for multiple comparisons were performed for significant parameters in ANOVA test.
  2. GI Gingival Index, PI Plaque Index, OHI-S Oral Hygiene Index Simplified, GBI Gingival Bleeding Index, PD Probing Depth, CAL clinical attachment loss, TGF-β1 transforming growth factor-β1, PDGF platelet-derived growth factor, IL-6 Interleukin-6, GCF gingival crevicular fluid, UD undetected.
  3. Data was expressed as mean ± S.E.M, *p < 0.05, **p < 0.01, ***p < 0.001.
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