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Figure 2

From: Loss of sympathetic innervation to islets of Langerhans in canine diabetes and pancreatitis is not associated with insulitis

Figure 2

Selective β-cell loss in dogs with spontaneous diabetes mellitus (DM) and dogs with pancreatitis and concurent DM. sDM Spontaneous DM, sDMPanc spontaneous DM and concurrent pancreatitis, sPanc spontaneous pancreatitis. (A) Pancreatic β-cells are significantly reduced in numbers/islet in pancreata of dogs with spontaneous DM and dogs with pancreatitis and DM compared with normal control dogs and dogs with pancreatitis and no DM. (B) There is no significant difference in pancreatic α-cell numbers/islet between all groups. Reprasentative immunofluorescence confocal images of insulin (green), glucagon (red) and DNA (blue) representing β-cells, α-cells and nuclei, respectively, in pancreate from (C) normal control dogs compared to (D) dogs with DM, (E) DM and (F) pancreatitis and pancreatitis only. p-values represented by *** (P ≤ 0.001) and **** (P ≤ 0.0001).

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