Figure 5
From: Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis
Anti-IL-6 antibody is able to eliminate blast cells in Pax5+/- leukemic mice. (a) IL-6 serum levels in Pax5+/- leukemic mice treated with anti-IL-6 (n = 5–3). Error bars represent the mean and SD. For the significant differences, an unpaired t-test was used (***; p-value < 0.0001). (b) B-ALL cells were decreased in 3 out of 6 Pax5+/- mice after anti-IL-6 treatment. (c–d) FACs analysis of PB and BM showing the reduction of blast cells in a responder Pax5+/- leukemic mouse due to anti-IL-6 treatment.
