Table 2 Top 17 candidate miRNAs identified in microarray analysis deregulated between ME/CFS and healthy matched controls.

From: Profile of circulating microRNAs in myalgic encephalomyelitis and their relation to symptom severity, and disease pathophysiology

miRNA

Fold difference

ME/CFS T0 versus CTRLS T0

hsa-miR-29a-3p

 + 2.00*

hsa-miR-150-5p

 + 2.86*

hsa-miR181b-5p

 + 2.77***

hsa-miR-4433a-5p

− 6.46***

hsa-miR-6819-3p

− 11.13***

ME/CFS T90 versus CTRLS T90

hsa-miR-127-3p

 + 2.86*

hsa-miR-140-5p

 + 3.74***

hsa-miR-150-5p

 + 2.93*

hsa-miR-374b-5p

 + 2.49***

hsa-miR-486-5p

− 2.13***

hsa-miR-3620-3p

− 2.47*

hsa-miR-5581-5p

 + 2.18*

hsa-miR-6076

 + 2.39*

hsa-miR-6507-3p

− 3.43*

hsa-miR-6717-5p

 + 3.68*

hsa-miR-6800-3p

− 2.88*

hsa-miR-6875-5p

 + 8.58*

ME/CFS T90 versus ME/CFS T0

hsa-miR-28-5p

 + 2.57***

hsa-miR-29a-3p

 + 1.98*

hsa-miR-140-5p

 + 2.79***

hsa-miR-374b-5p

 + 2.43**

hsa-miR-486-5p

− 2.03***

hsa-miR-6800-3p

− 2.65*

hsa-miR-6875-5p

 + 4.02*

CTRLS T90 versus CTRLS T0

hsa-miR-3620-3p

 + 3.72*

hsa-miR-6507-3p

 + 5.62*

  1. MiRNA expression profile using microarray analysis at baseline and T90 of ME/CFS and healthy matched controls. The data is represented as a fold difference.
  2. ANOVA was used to analyze the differences and measure the significance *P value < 0.05, **P value < 0.01, and ***P value < 0.001.
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