Table 3 miRNA expression differences between ME/CFS group and healthy controls by RT-qPCR in the replication phase.

From: Profile of circulating microRNAs in myalgic encephalomyelitis and their relation to symptom severity, and disease pathophysiology

miRNA

T0

T90

Fold difference

Fold difference

hsa-miR-28-5p

2.24 ± 0.47*

2.65 ± 0.97

hsa-miR-29a-3p

1.71 ± 0.33

1.73 ± 0.33

hsa-miR-127-3p

4.27 ± 0.78**

2.86 ± 0.47

hsa-miR-140-5p

3.08 ± 0.61**

2.00 ± 0.32

hsa-miR-150-5p

3.37 ± 1.05

8.61 ± 2.53*

hsa-miR-181b-5p

1.56 ± 0.29

1.72 ± 0.40

hsa-miR-374b-5p

2.70 ± 0.56*

2.00 ± 0.35

hsa-miR-486-5p

1.68 ± 0.20

3.02 ± 0.71*

hsa-miR-3620-3p

1.36 ± 0.15

3.30 ± 0.76*

hsa-miR-4433a-5p

1.87 ± 0.29*

2.37 ± 0.77

hsa-miR-6819-3p

2.18 ± 0.32*

2.47 ± 0.38

  1. miRNA expression profile differences between ME/CFS patients and matched controls in the replication phase. Data are shown at baseline (T0)and after stress test (T90)by fold difference.
  2. All data are represented as mean ± standard error of the mean. The results were considered significant at *P value < 0.05, and **P value < 0.01.
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