Figure 6

Assessment of Ca2+ handling on isolated cells. Panel (a) shows identical current–voltage relationship of L-type Ca2+ current between groups. Panel (b) illustrates significantly larger inward current as a response of 10 mM caffeine application. Panel (c,d) reports larger Ca2+ transient amplitude in the case of trained rats (red trace) compared to control (black trace). Panel (e) indicates faster transient relaxation kinetics in the case of trained animals.