Table 1 Study arms and product characteristics.

From: A randomised controlled single-centre open-label pharmacokinetic study to examine various approaches of nicotine delivery using electronic cigarettes

Products

Short code

Article

Category

Brand

Nicotine conc. (mg/mL)

Protonation levels

Flavour

Puff protocol

A

N/A

Control

Cigarette

B&H Skybluea

N/A

N/A

N/A

Ad libitum

B

N/A

Control

Cigarette

B&H Skybluea

N/A

N/A

N/A

Fixed

C

ePen2.0BT18

Comparator

e-cigarette

Vype ePen

18

Unprotonated

Blended Tobacco

Ad libitum

D

ePen3.0BT18

Test #1

e-cigarette

Vype ePen3

18

Unprotonated

Blended Tobacco

Ad libitum

E

ePen3.0MB18VP

Test #2

e-cigarette

Vype ePen3

18

Medium protonation

MasterBlend Tobacco

Ad libitum

F

ePen3.0MB30VP

Test #3

e-cigarette

Vype ePen3

30

High protonation

MasterBlend Tobacco

Ad libitum

G

ePen3.0MB18VP

Test #4

e-cigarette

Vype ePen3

18

Medium protonation

MasterBlend Tobacco

Fixed

H

ePen3.0MB12VP

Test #1

e-cigarette

Vype ePen3

12

Low protonation

MasterBlend Tobacco

Ad libitum

  1. N/A not applicable.
  2. aBenson & Hedges Skyblue—7 mg ISO tar cigarette.