Figure 3 | Scientific Reports

Figure 3

From: Inactivation of mediator complex protein 22 in podocytes results in intracellular vacuole formation, podocyte loss and premature death

Figure 3

Histological analysis of pod-Med22 mice show formation of vesicular structures in podocytes followed by development of glomerulosclerosis. (A) No histological abnormalities are detected in 8-week old mice as shown by PAS staining. (B) At 12 weeks, numerous glomerular and tubulointerstitial abnormalities are detected. In glomeruli, focal segmental sclerosis (arrow) is detected and large vesicular structures (*) are observed. Tubuli show hyaline casts and dilation, and interstitial fibrosis is observed. (C) At 16 weeks of age, most glomeruli are completely sclerotic. Tubuli show more pronounced dilation and hyaline casts. (D) Semi-quantification of histological changes in pod-Med22 mice versus littermate control mice. There is a significant increase in a proportion of abnormal glomeruli, the presence of glomerular vacuoles and tubular casts at both 12 and 16 weeks of age. G glomerulus; TC tubular casts. ***p < 0.001.

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