Figure 1 | Scientific Reports

Figure 1

From: Toll-like receptor 4 regulates intestinal fibrosis via cytokine expression and epithelial-mesenchymal transition

Figure 1

Comparison of clinical indices, gross appearance, and histologic grading in toll-like receptor 4-deficient (TLR4−/−) (n = 5) and wild-type mice (n = 5). (A) Wild-type mice experienced extensive weight loss compared to TLR4−/− mice during post dextran sulfate sodium treatment. (B) Disease activity index from day 5 to day 20 was higher in wild-type as compared to TLR4−/− mice. (C) Gross appearance of extracted colons showed bowel edema and fibrotic change in wild-type mice. However, in TLR4−/− mice, bowel edema was not marked. (D) Colon from TLR4−/− mice was longer than that from wild-type mice. Asterisks indicate significant differences (P-values < 0.05) between TLR4−/− and wild-type mice.

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