Table 2 Bioactivity of synthesized compounds in inhibits LDHA and LDHB.
Entry | Compounds | LDHA IC50 | LDHB IC50 | LDHB/LDHA |
|---|---|---|---|---|
1 | 1 | > 1000 µM | 79.05 µM | ND |
2 | 2 | 13.63 µM | 395.3 µM | 29.00 |
3 | 3 | > 1000 µM | 150.8 µM | ND |
4 | 4 | 182.5 µM | 7.87 µM | 0.043 |
5 | 5 | 477.5 µM | > 1000 µM | 2.094 |
6 | 6 | 452.5 µM | 129.8 µM | 0.29 |
7 | 7 | 842.6 µM | > 1000 µM | > 1.18 |
8 | 8 | > 1000 µM | 248 µM | ND |
9 | 9 | > 1000 µM | 151.1 µM | ND |
10 | 10 | 47.20 µM | > 1000 µM | > 21.18 |
11 | GSK2837808A | 2.6 nM | 130.3 nM | 50.12 |
12 | GNE140 | 59.9 nM | 151.1 nM | 2.52 |
