Figure 5

Baseline electrophysiological characterization of transmural tissue block slices and transmural core biopsy slices from pigs. (A) Temporally averaged AP for the 20-s transmembrane voltage recording of a point in a tissue block slice (left) and a point in a transmural biopsy slice (right). (B) Representative pseudo-color APD and activation time maps at a pacing frequency of 1 Hz for a tissue block slice (left panels) and a transmural biopsy slice (right panels) from the same pig. Crosses indicate the exact pixels for which averaged APs are shown in (A). (C) Histograms showing the APD distributions (bars) for all tissue block slices (p/n/N = 36/12/4) and all transmural biopsy slices (p/n/N = 36/12/4), along with optimally fitted kernel smoothing functions (lines). Differences between the two APD distributions were not statistically significant according to Mann–Whitney U-test.