Table 2 Independent predictors for breast cancer in all patients of the two cohorts during the overall follow-up period.

Variable	Crude model HR^SD (95% CI)	p value	Full model HR^SD (95% CI)*	p value
Cohort
Comparison	1 (reference)		1 (reference)
COP	0.67 (0.50–0.91)	0.009	0.67 (0.50–0.90)	0.009
Age (years)
20–34	1 (reference)		1 (reference)
35–49	4.72 (3.70–6.01)	< 0.001	4.67 (3.66–5.96)	< 0.001
50–64	6.60 (4.96–8.78)	< 0.001	6.03 (4.49–8.10)	< 0.001
≥ 65	2.96 (1.62–5.42)	< 0.001	2.17 (1.07–4.39)	0.031
Comorbidity
Hypertension	2.68 (1.87–3.84)	< 0.001	1.78 (1.16–2.73)	0.008
Diabetes	1.70 (0.64–4.53)	0.292	0.87 (0.29–2.67)	0.813
Hyperlipidemia	2.82 (1.17–6.81)	0.021	1.28 (0.46–3.52)	0.637
Monthly income (NTD)
< 20,000	0.80 (0.62–1.02)	0.070	0.75 (0.59–0.97)	0.029
20,000–40,000	0.77 (0.60–1.01)	0.057	0.79 (0.61–1.03)	0.087
> 40,000	1 (reference)		1 (reference)
Geographic region
North	1 (reference)		1 (reference)
Center	0.65 (0.50–0.85)	0.002	0.76 (0.58–0.99)	0.045
South	0.84 (0.68–1.05)	0.126	0.91 (0.72–1.13)	0.385
East	0.55 (0.23–1.34)	0.190	0.67 (0.28–1.64)	0.384

The independent predictors were identified through competing risk regression analysis.
COP carbon monoxide poisoning, HR hazard ratio, AHR adjusted hazard ratio, HR^SD adjusted competing risks hazard ratio, CI confidence interval, NTD New Taiwan Dollars.
*Adjusted for age, hypertension, diabetes, hyperlipidemia, monthly income, and geographic region.

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