Figure 2
EPCR deficiency exacerbates the DSS-induced colitis in mice: Wild-type and EPCR−/− mice were treated with DSS (2.5% w/v) in the drinking water for 10 days. The disease activity index (DAI) was monitored during the course of colitis based on body weight loss, diarrhea, and fecal blood. The body weight loss (A) and DAI (B) were calculated as described in Methods. (C) Representative pictures of the colon from the control (H2O) and DSS-treated mice. (D) The colon length of control and DSS-treated mice. Data are the mean ± SEM of 2 independent experiments of 8 mice/group. *P < 0.05; **P < 0.01; ***P < 0.001.
