Figure 4

Patterns of amyloid–cortical thickness values extended to all cortical parcels. (A) Scatter plot for all 34 cortical parcels (each an average of both hemispheres). Each parcel was subanalyzed separately classified by the MoCA score of the patient (red: MoCA score 0–10; blue: MoCA score 11–19; yellow: MoCA score 20–30). Each dot is an average of the cortical thickness and amyloid (SUVR) for each parcel, for all patients in the group indicated by the color. Overlaid crosshairs show the means and standard deviations for the three groups. (B) Scatter plot of the same data points from (A) but with overlaid lines connecting the points belonging to the same parcel. (C) Similar scatter plot as shown in (A) and (B) but with each parcel normalized to a common cortical amyloid SUVR (1.0) and cortical thickness value (0.0) for the high MoCA score group (yellow circles). The parcels were grouped into 2 categories (thicker or thinner) depending on how the high MoCA group (yellow circles) compared with the middle MoCA group (blue circles). This shows the trend of decreased cortical thickness from high MoCA to low MoCA groups. (D) Surface image of an inflated brain using data from (C), showing the spatial variation from a simple dichotomization from (C) (i.e., between high MoCA to medium MoCA. The regions of less thinning generally occur in the frontal parenchyma, Heschl’s gyrus, and calcarine sulcus. MoCA Montreal Cognitive Assessment, SUVR standardized uptake value ratio.