Table 2 Statistical significance of correlations between cortical amyloid and cortical thickness for all FreeSurfer cortical parcels, using a simple model (regression of regional amyloid vs cortical thickness) and a multivariable model (comparing regional amyloid as a function of cortical thickness, age, education, sex, and MoCA score).

Frontal pole

− 0.352 [− 0.813, 0.109]

− 0.331 [− 0.773, 0.112]

0.002 [− 0.012, 0.016]

− 0.016 [− 0.043, 0.011]

− 0.111 [− 0.294, 0.073]

− 0.019** [− 0.005, − 0.034]

Lateral orbitofrontal

− 0.473 [− 1.107, 0.160]

− 0.109 [− 0.668, 0.500]

0.008 [− 0.004, 0.021]

− 0.021 [− 0.045, 0.003]

− 0.095 [− 0.259, 0.068]

− 0.027**** [− 0.039, − 0.014]

Medial orbitofrontal

− 0.349 [− 1.232, 0.534]

− 0.123 [− 0.910, 0.664]

0.008 [− 0.009, 0.025]

− 0.040* [− 0.073, − 0.008]

0.017 [− 0.210, 0.244]

− 0.035**** [− 0.053, − 0.018]

Pars orbitalis

− 0.512 [− 1.139, 0.114]

− 0.468 [− 0.973, 0.037]

0.004 [− 0.010, 0.018]

− 0.024 [− 0.050, 0.002]

− 0.250** [− 0.430, − 0.070]

− 0.033***** [− 0.047, − 0.019]

Pars triangularis

− 0.850 [− 2.011, 0.310]

− 0.750 [− 1.69, 0.178]

0.010 [− 0.009, 0.029]

− 0.036 [− 0.073, 0.001]

− 0.174 [− 0.427, 0.079]

− 0.053***** [− 0.073, − 0.033]

Pars opercularis

− 1.295* [− 2.422, − 0.148]

− 0.531 [− 1.518, 0.455]

0.007 [− 0.012, 0.026]

− 0.043* [− 0.079, − 0.007]

0.029 [− 0.218, 0.277]

− 0.050***** [− 0.070, − 0.030]

Rostral middle frontal

− 0.552 [− 1.765, 0.661]

− 0.673 [− 1.606, 0.260]

0.005 [− 0.013, 0.022]

− 0.043* [− 0.077, − 0.009]

0.027 [− 0.205, 0.259]

− 0.056***** [− 0.074, − 0.038]

Caudal middle frontal

− 1.177** [− 2.013, − 0.342]

− 0.922** [− 1.563, − 0.281]

0.006 [− 0.010, 0.023]

− 0.042** [− 0.073, − 0.010]

0.101 [− 0.113, 0.314]

− 0.053***** [− 0.070, − 0.036]

Superior frontal

− 0.953* [− 1.743, − 0.162]

− 0.837* [− 1.486, − 0.189]

0.002 [− 0.014, 0.018]

− 0.041** [− 0.071, − 0.010]

0.081 [− 0.129, 0.292]

− 0.043***** [− 0.059, − 0.026]

Paracentral

− 0.281 [− 0.939, 0.376]

0.027 [− 0.514, 0.568]

0.007 [− 0.009, 0.022]

− 0.032* [− 0.061, − 0.003]

− 0.012 [− 0.212, 0.187]

− 0.044***** [− 0.060, − 0.029]

Precentral

0.061 [− 0.574, 0.696]

0.233 [− 0.269, 0.734]

0.007 [− 0.006, 0.021]

− 0.037** [− 0.063, − 0.012]

− 0.082 [− 0.257, 0.094]

− 0.036***** [− 0.050, − 0.023]

Postcentral

0.238 [− 0.678, 1.153]

0.276 [− 0.415, 0.967]

0.002 [− 0.012, 0.016]

− 0.036* [− 0.064, − 0.008]

− 0.206* [− 0.394, − 0.018]

− 0.043***** [− 0.058, − 0.028]

Superior parietal

− 0.704 [− 1.447, 0.038]

− 0.128 [− 0.779, 0.523]

0.006 [− 0.009, 0.021]

− 0.032* [− 0.061, − 0.002]

− 0.011 [− 0.210, 0.188]

− 0.041***** [− 0.057, − 0.024]

Inferior parietal

− 2.527***** [− 3.343, − 1.711]

− 1.853***** [− 2.617, − 1.090]

0.015 [− 0.001, 0.031]

− 0.039* [− 0.069, − 0.009]

− 0.047 [− 0.255, 0.160]

− 0.034*** [− 0.052, − 0.016]

Supramarginal

− 1.811*** [− 2.735, − 0.887]

− 1.020* [− 1.804, − 0.236]

0.011 [− 0.006, 0.027]

− 0.042** [− 0.073, − 0.010]

− 0.098 [− 0.315, 0.119]

− 0.044***** [− 0.062, − 0.027]

Precuneus

− 1.403** [− 2.281, − 0.525]

− 0.764 [− 1.627, 0.099]

0.003 [− 0.017, 0.023]

− 0.035 [− 0.073, 0.003]

0.069 [− 0.194, 0.332]

− 0.040*** [− 0.062, − 0.018]

Cuneus

− 0.359 [− 1.389, 0.671]

− 0.197 [− 1.098, 0.704]

0.022* [0.003, 0.042]

− 0.023 [− 0.061, 0.015]

− 0.090 [− 0.344, 0.165]

− 0.043**** [− 0.063, − 0.023]

Peri-calcarine

0.410 [− 0.863, 1.684]

0.466 [− 0.593, 1.525]

0.022 [− 0.001, 0.046]

− 0.002 [− 0.048, 0.043]

0.009 [− 0.302, 0.319]

− 0.068***** [− 0.092, − 0.044]

Lateral occipital

− 1.213*** [− 1.915, − 0.512]

− 0.781* [− 1.454, − 0.108]

0.011 [− 0.004, 0.026]

− 0.035* [− 0.064, − 0.005]

− 0.032 [− 0.229, 0.164]

− 0.033**** [− 0.050, − 0.017]

Fusiform

− 0.725**** [− 1.063, − 0.387]

− 0.285 [− 0.726, 0.156]

0.001 [− 0.010, 0.011]

− 0.019 [− 0.040, 0.002]

− 0.069 [− 0.213, 0.076]

− 0.019* [− 0.034, − 0.005]

Lingual

− 0.317 [− 0.964, 0.329]

− 0.003 [− 0.616, 0.610]

0.007 [− 0.006, 0.019]

− 0.012 [− 0.037, 0.013]

− 0.121 [− 0.287, 0.044]

− 0.026*** [− 0.040, − 0.013]

Temporal pole

− 0.138 [− 0.377, 0.100]

− 0.057 [− 0.304, 0.190]

0.000 [− 0.012, 0.0120]

− 0.015 [− 0.037, 0.008]

− 0.104 [− 0.258, 0.051]

− 0.008 [− 0.020, 0.005]

Superior temporal

− 1.863***** [− 2.446, − 1.281]

− 1.113*** [− 1.732, − 0.494]

0.010 [− 0.004, 0.023]

− 0.026* [− 0.051, − 0.001]

− 0.004 [− 0.177, 0.168]

− 0.028*** [− 0.043, − 0.013]

Middle temporal

− 1.777***** [− 2.205, − 1.350]

− 1.366***** [− 1.879, − 0.853]

0.014** [0.004, 0.025]

− 0.018 [− 0.038, 0.003]

− 0.044 [− 0.182, 0.094]

− 0.010 [− 0.024, 0.003]

Inferior temporal

− 0.939**** [− 1.369, − 0.509]

− 0.502* [− 0.944, − 0.059]

0.009 [− 0.001, 0.020]

− 0.025* [− 0.046, − 0.004]

− 0.011 [− 0.154, 0.131]

− 0.022** [− 0.035, − 0.009]

Entorhinal

− 0.058 [− 0.206, 0.091]

− 0.016 [− 0.183, 0.150]

0.003 [− 0.008, 0.014]

− 0.015 [− 0.034, 0.005]

0.025 [− 0.110, 0.161]

− 0.002 [− 0.014, 0.009]

Parahippocampal

− 0.162 [− 0.407, 0.084]

− 0.087 [− 0.342, 0.168]

− 0.002 − 0.013, 0.009]

− 0.020* [− 0.041, − 0.000]

− 0.016 [− 0.154, 0.121]

− 0.010 [− 0.021, 0.001]

Insula

− 0.487 [− 0.989, 0.014]

− 0.207 [− 0.716, 0.303]

0.004 [− 0.008, 0.015]

− 0.029* [− 0.052, − 0.006]

0.099 [− 0.059, 0.257]

− 0.020** [− 0.034, − 0.006]

Transverse temporal

− 0.716 [− 1.455, 0.023]

− 0.426 [− 1.094, 0.243]

0.023* [0.001, 0.045]

− 0.046* [− 0.087, − 0.006]

0.081 [− 0.195, 0.356]

− 0.044**** [− 0.066, − 0.023]

Banks

− 3.085***** [− 4.125, − 2.045]

− 2.003*** [− 3.144, − 0.863]

0.017 [− 0.006, 0.040]

− 0.048* [− 0.093, − 0.004]

0.147 [− 0.159, 0.454]

− 0.045** [− 0.073, − 0.017]

Caudal anterior cingulate

− 0.316 [− 0.821, 0.188]

− 0.206 [− 0.670, 0.258]

0.009 [− 0.009, 0.026]

− 0.038* [− 0.072, − 0.005]

0.124 [− 0.108, 0.355]

− 0.029** [− 0.047, − 0.011]

Rostral anterior cingulate

− 0.414 [− 0.959, 0.130]

− 0.491* [− 0.959, − 0.023]

0.015 [− 0.005, 0.035]

− 0.046* [− 0.085, − 0.007]

0.069 [− 0.198, 0.336]

− 0.044**** [− 0.065, − 0.023]

Isthmus cingulate

− 0.661** [− 1.133, − 0.189]

− 0.552* [− 1.050, − 0.054]

− 0.004 [− 0.022, 0.013]

− 0.022 [− 0.055, 0.011]

0.012 [− 0.217, 0.241]

− 0.013 [− 0.032, 0.006]

Posterior cingulate

− 0.153 [− 0.721, 0.415]

− 0.184 [− 0.742, 0.374]

0.002 [− 0.019, 0.024]

− 0.040 [− 0.082, 0.002]

0.085 [− 0.201, 0.371]

− 0.022 [− 0.044, 0.001]