Figure 4 | Scientific Reports

Figure 4

From: Fibrinolysis-resistant carbonylated fibrin detected in thrombi attached to the vascular wall of abdominal aortic aneurysms

Figure 4

Loss of enhancing effect of 6AHA on uPA-catalyzed Glu1-plasminogen activation after conversion to N-acetyl FDP-6AHA. 6AHA enhanced uPA-catalyzed Glu1-plasminogen activation in a dose-dependent manner (control 6AHA). After incubation with acrolein at different molar ratios (1:2 and 1:4), 6AHA lost its enhancing effect on Glu1-plasminogen activation in an acrolein concentration-dependent manner. When 6AHA was incubated with acrolein solution after evaporation, however, Glu1-plasminogen activation was enhanced in a dose-dependent manner as was control 6AHA.

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