Figure 1
From: TRPM2 promotes autophagic degradation in vascular smooth muscle cells
Knockout of TRPM2 reduced starvation-induced LC3 II and P62 degradation. (A, B) Representative western blot images (A) and data summary (B) showing starvation (3–24 h)-induced LC3 II change in mASMCs in the presence or absence of bafilomycin A1 (BafA1, 30 nM) treatment. (C, D) Representative western blot images (C) and data summary (D) comparing 3 h starvation-induced LC3 II change in mASMCs between WT and TRPM2 KO mice. (E, F) Representative western blot images (C) and data summary (D) comparing 3 h starvation-induced p62 change in mASMCs between WT and TRPM2 KO mice. WT stands for wild-type; KO stands for knockout. Values are mean ± SEM (n = 3–8, *P < 0.05, **P < 0.01, ***P < 0.001; ns = not significant). One-way ANOVA was used for statistical test.
