Figure 5

Behavioral deficits of stroke mice in the WMT. (A,B) show the cognitive deficits of HI mice in the spatial navigating training of the WMT at 4 weeks after stroke. Increased decay time (A) and longer swimming distances (B) to the platform showed in HI mice than those of sham mice in the training of the WMT. (C) Similar swimming speeds in sham and HI groups. (D)–(F) Sham and HI mice showed no significant differences in the probe test, including the time spent in the periphery, the opposite and the target quadrants (D), the time spent before the first entry to the platform zone (E), the crossing numbers (F). Data are shown as the mean and SEM for each group. Two-way repeated ANOVA followed by fisher multiple comparison test in (A,B) or unpaired t-test in (C)–(F), *P < 0.05, **P < 0.01. N = 19 mice per group.