Table 5 List of top 20 up and down regulated transcripts in tobacco-flavored e-liquids.
Gene name | HGNC. ID | Full description of the gene | Fold change (log2) | p value |
|---|---|---|---|---|
Up regulated genes | ||||
CYP4F3 | 2646 | Cytochrome P450 family 4 subfamily F member 3 | 7.342 | 0.002 |
HKDC1 | 23302 | Hexokinase domain containing 1 | 6.075 | 0.000 |
IL1RL1 | 5998 | Interleukin 1 receptor like 1 | 5.059 | 0.000 |
SLC7A11 | 11059 | Solute carrier family 7 member 11 | 5.024 | 0.000 |
AKR1C1 | 384 | Aldo–keto reductase family 1 member C1 | 4.896 | 0.000 |
MCTP1 | 26183 | Multiple C2 and transmembrane domain containing 1 | 4.889 | 0.000 |
KIAA0319 | 21580 | KIAA0319 | 4.870 | 0.000 |
PTGS2 | 9605 | Prostaglandin-endoperoxide synthase 2 | 4.831 | 0.000 |
TRIM36 | 16280 | Tripartite motif containing 36 | 4.830 | 0.000 |
RORA | 10258 | RAR related orphan receptor A | 4.775 | 0.000 |
FOSB | 3797 | FosB proto-oncogene, AP-1 transcription factor subunit | 4.734 | 0.002 |
KRT34 | 6452 | Keratin 34 | 4.648 | 0.001 |
RRAGD | 19903 | Ras related GTP binding D | 4.603 | 0.000 |
NEFM | 7734 | Neurofilament, medium polypeptide | 4.591 | 0.000 |
MYEF2 | 17940 | Myelin expression factor 2 | 4.407 | 0.000 |
UNC13A | 23150 | Unc-13 homolog A | 4.402 | 0.000 |
RASD1 | 15828 | Ras related dexamethasone induced 1 | 4.394 | 0.001 |
CXCL8 | 6025 | C-X-C motif chemokine ligand 8 | 4.276 | 0.000 |
MAP1B | 6838 | Microtubule associated protein 1B | 4.264 | 0.000 |
CYP1A1 | 2595 | Cytochrome P450 family 1 subfamily A member 1 | 4.173 | 0.000 |
Down regulated genes | ||||
INPP5D | 6079 | Inositol polyphosphate-5-phosphatase D | − 6.157 | 0.000 |
CA9 | 1383 | Carbonic anhydrase 9 | − 5.774 | 0.000 |
HPDL | 28242 | 4-hydroxyphenylpyruvate dioxygenase like | − 5.386 | 0.000 |
PRODH | 9453 | Proline dehydrogenase 1 | − 4.630 | 0.000 |
MMP28 | 14366 | Matrix metallopeptidase 28 | − 4.610 | 0.001 |
LRFN1 | 29290 | Leucine rich repeat and fibronectin type III domain containing 1 | − 4.533 | 0.000 |
ZNF488 | 23535 | Zinc finger protein 488 | − 4.431 | 0.000 |
NKPD1 | 24739 | NTPase, KAP family P-loop domain containing 1 | − 4.395 | 0.000 |
KANK4 | 27263 | KN motif and ankyrin repeat domains 4 | − 4.277 | 0.000 |
CDH8 | 1767 | Cadherin 8 | − 4.230 | 0.001 |
HBQ1 | 4833 | Hemoglobin subunit theta 1 | − 4.228 | 0.000 |
PLCB2 | 9055 | Phospholipase C beta 2 | − 4.159 | 0.000 |
KRT81 | 6458 | Keratin 81 | − 4.065 | 0.000 |
PYCRL | 25846 | Pyrroline-5-carboxylate reductase-like | − 4.056 | 0.000 |
RDH16 | 29674 | Retinol dehydrogenase 16 (all-trans) | − 4.052 | 0.000 |
STEAP3 | 24592 | STEAP3 metalloreductase | − 4.030 | 0.000 |
ID1 | 5360 | INHIBITOR of DNA binding 1, HLH protein | − 3.948 | 0.000 |
GCK | 4195 | Glucokinase | − 3.933 | 0.000 |
KRT7 | 6445 | Keratin 7 | − 3.910 | 0.000 |
LARGE2 | 16522 | LARGE xylosyl- and glucuronyltransferase 2 | − 3.879 | 0.000 |
