Figure 2
From: SHROOM3, the gene associated with chronic kidney disease, affects the podocyte structure
The association with si-Shroom3 injection and albuminuria. (a) The scheme of the experiment using tdTomato-Podocin reporter mice. TPFE-siRNA complexes were injected and sacrificed three days later. (b) Albuminuria before and after TPFE-siRNA complexes injection. Before injection, urinary albumin was not different between mice with scramble siRNA and si-Shroom3. Urinary albumin significantly increased in 72 h post si-Shroom3 injection while urinary albumin did not increase in mice with scramble siRNA. (c) Urinary podocytes per high field were more in mice with si-Shroom3 than in mice with negative control siRNA. n = 5 for each.
