Table 2 Relationship between expression levels of genes affected by FeCl3 in rat primary hepatocytes.

From: Response to iron overload in cultured hepatocytes

		Ribosomal protein		Autophagy/stress-related			Cell signaling			Protein phosphatase		Transcription factor			Transporter				Transmembrane protein
		Mrpl54	Mrps24	Atg5	Ern1	Nrbf2	Fgfr2	Tnfrs1b	Jnk1	Ppp6c	Ppp6r1	Gabpa	Hes6	Tfam	Slc1a4	Slc16a7	Slc30a9	Zip14	Tmem5	Tmem120a	Tmem126a
Ribosomal protein	Mrpl54	–	0.774	0.735	0.703	0.669	0.678	0.649	0.530	0.782	0.636	0.561	0.671	0.764	0.721	0.726	0.691	0.676	0.707	0.855	0.827
	Mrpl54		< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	0.008	< 0.001	< 0.001	0.004	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
	Mrps24		–	0.725	0.839	0.795	0.826	0.830	0.725	0.802	0.805	0.579	0.888	0.782	0.838	0.839	0.855	0.869	0.722	0.899	0.791
	Mrps24			< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	0.003	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
Autophagy/stress-related	Atg5			–	0.841	0.591	0.750	0.680	0.607	0.783	0.793	0.574	0.631	0.708	0.783	0.806	0.783	0.723	0.726	0.728	0.739
	Atg5				< 0.001	0.003	< 0.001	< 0.001	0.002	< 0.001	< 0.001	0.004	0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
	Ern1				–	0.769	0.912	0.900	0.761	0.858	0.853	0.643	0.831	0.699	0.897	0.936	0.817	0.933	0.824	0.814	0.820
	Ern1					< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
	Nrbf2					–	0.735	0.801	0.530	0.653	0.607	0.383	0.716	0.441	0.624	0.736	0.624	0.723	0.526	0.752	0.773
	Nrbf2						< 0.001	< 0.001	0.008	< 0.001	0.002	0.07	< 0.001	0.03	0.001	< 0.001	0.001	< 0.001	0.008	< 0.001	< 0.001
Cell signaling	Fgfr2						–	0.929	0.845	0.839	0.802	0.451	0.812	0.720	0.885	0.936	0.831	0.935	0.808	0.842	0.819
	Fgfr2							< 0.001	< 0.001	< 0.001	< 0.001	0.03	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
	Tnfrs1b							–	0.780	0.809	0.740	0.373	0.784	0.662	0.855	0.887	0.809	0.918	0.776	0.815	0.812
	Tnfrs1b								< 0.001	< 0.001	< 0.001	0.07	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
	Jnk1								–	0.726	0.830	0.510	0.714	0.761	0.721	0.816	0.803	0.835	0.806	0.656	0.637
	Jnk1									< 0.001	< 0.001	0.01	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
Protein phosphatase	Ppp6c									–	0.739	0.664	0.732	0.870	0.867	0.876	0.880	0.850	0.809	0.831	0.853
	Ppp6c										< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
	Ppp6r1										–	0.659	0.770	0.786	0.837	0.839	0.872	0.862	0.817	0.747	0.668
	Ppp6r1											< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
Transcription factor	Gabpa											–	0.570	0.646	0.591	0.580	0.594	0.568	0.539	0.518	0.533
	Gabpa												0.004	< 0.001	0.002	0.003	0.002	0.004	0.007	0.01	0.007
	Hes6												–	0.694	0.779	0.796	0.747	0.806	0.680	0.762	0.713
	Hes6													< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
	Tfam													–	0.798	0.727	0.888	0.749	0.814	0.790	0.771
	Tfam														< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
Transporter	Slc1a4														–	0.897	0.911	0.926	0.865	0.864	0.788
	Slc1a4															< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
	Slc16a7															–	0.857	0.939	0.828	0.821	0.784
	Slc16a7																< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
	Slc30a9																–	0.866	0.814	0.808	0.798
	Slc30a9																	< 0.001	< 0.001	< 0.001	< 0.001
	Slc39a14																	–	0.865	0.843	0.789
	Slc39a14																		< 0.001	< 0.001	< 0.001
Transmembrane protein	Tmem5																		–	0.758	0.726
	Tmem5																			< 0.001	< 0.001
	Tmem120a																			–	0.856
	Tmem120a																				< 0.001
	Tmem126a																				–

Upper: correlation coefficient. Lower: P value.

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Table 2 Relationship between expression levels of genes affected by FeCl3 in rat primary hepatocytes.

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