Figure 3 | Scientific Reports

Figure 3

From: Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis

Figure 3

Jα18−/− mice lacking Vα14 iNKT cells fail to respond to α-GalCer treatment and show no change in iron metabolism. Wild-type (Wt) and Jα18−/− mice were injected with vehicle or 100 μg/kg body weight of α-GalCer. (A) Liver weight 24 h post-treatment. (B) Serum iron at 6 h and 24 h post-treatment. (C) Hepcidin mRNA expression at 6 h and 24 h post-treatment. Each symbol represents one mouse with the bar indicating the mean; n = 8 per group. Statistical analysis was performed with one-way ANOVA. n.s. not significant compared to control mice injected with vehicle.

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