Figure 1

An overview of the differentially expressed genes (DEGs) between the wild-type and parp-1^−/− groups: (A) Comparison between the number of DEGs downregulated in parp-1^−/− larvae (downregulated DEGs) and the number of DEGs upregulated in parp-1^−/− larvae (upregulated DEGs). (B) Heat map representing the differences in expression level for all DEGs between wild type (WT) and the parp-1^−/− (P^−/−) flies. Biological replicates are shown separately. The expression level of each gene was normalized to the average level of expression of all genes. Negative values (in blue shading) represent the downregulated DEGs, while positive values (in red shading) represent the upregulated DEGs. The last column represents the fold difference between the wild type and parp-1^−/− groups. The fold difference was measured as the negative expression level in the wild type larvae divided by the expression level in the parp-1^−/− larvae when the expression was higher in the wild type group (shown in blue) and the expression level in parp-1^−/− larvae divided by the expression level in wild type larvae when the expression was higher in the parp-1^−/− group (shown in red). (C) Distribution of the 602 DEGs, depending on the fold difference of their expression level between the wild type and parp-1^−/− groups.