Figure 6 | Scientific Reports

Figure 6

From: Local environment effects on charged mutations for developing aggregation-resistant monoclonal antibodies

Figure 6

(a, b) Residue-wise decomposition of \(\Delta G_{\mathrm{solv}}\) for (a) RRR-A\(\beta\)18-27 and (b) DDD-A\(\beta\)18-27 mutants of A\(\beta\)18-27 dAb (blue, red and black colors refer to positively charged, negatively charged and neutral residues, respectively). The mutation sites are indicated by the green arrow. \(d_{\mathrm{m}}\) (in Å) denotes the distance to the mutation sites as illustrated in the inset (green dashed oval, mutation sites; cyan and orange stick representations, positively and negatively charged residues, respectively). Residues involved in the formation/breaking of salt-bridges upon mutation are represented by SB \(+/-\) (green if the mutation sites are involved, and black otherwise). PyMOL version 1.8.2 (https://pymol.org) was used to generate protein figures.

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