Table 3 PPI consumption and risk of non-AD dementias according to dose and age groups.

From: Proton pump inhibitors and the risk of Alzheimer’s disease and non-Alzheimer’s dementias

 

Unadjusted OR (95% CI)

Adjusted* OR (95% CI)

All

Dose consumed

< 28 DDD

Ref.

Ref.

28–83 DDD

0.89 (0.62–1.28)

0.72 (0.50–1.04)

> 83 DDD

2.24 (1.76–2.87)

0.95 (0.74–1.22)

< 65 years

Dose consumed

< 28 DDD

Ref.

Ref.

28–83 DDD

NA**

NA**

> 83 DDD

3.43 (0.51–67.09)

2.32 (0.33–45.88)

65–80 years

Dose consumed

< 28 DDD

Ref.

Ref.

28–83 DDD

0.83 (0.41–1.60)

0.78 (0.39–1.53)

> 83 DDD

1.32 (0.84–2.15)

1.02 (0.65–1.67)

> 80 years

Dose consumed

< 28 DDD

Ref.

Ref.

28–83 DDD

0.67 (0.42–1.02)

0.67 (0.43–1.04)

> 83 DDD

0.86 (0.64–1.16)

0.83 (0.62–1.13)

  1. CI confidence interval, OR odds ratio, PPI proton pump inhibitor.
  2. *Adjusted by age, sex, hypertension, diabetes, dyslipidaemia.
  3. ** < 28 DDD (N = 3,075), 29–83 DDD (N = 13,183), > 83 DDD (N = 20,102).
  4. *** < 65 years old (N = 68,785), 65–80 years old (N = 42,067), > 80 years old (N = 24,870).
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