Figure 2
Molecular description of CLL microenvironment and targets. (A) 139 proteins (effectors) selected as descriptors of the CLL microenvironment and the relations between them. (B) Extract of the network build around the selected effectors of the microenvironment that contains the targets for the 65 screened compounds. Dark green square: CLL microenvironment selected descriptors; Light green round: Proteins directly related with selected CLL microenvironment descriptors; Orange, round: Protein targets of the 65 screened compounds that lay within the network described by the microenvironment effector proteins and close neighbours; Red square: Proteins that are effectors and targets simultaneously. The images haven been developed with Cytoscape v3.7.2 software51.
