Table 3 Univariate and multivariate analyses of prognostic factors.
Variables | Overall survival | Relapse | |||||||
|---|---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | ||||||
HR (95%CI) | p | HR (95%CI) | p | HR (95%CI) | p | HR (95%CI) | p | ||
Factors at diagnosis | |||||||||
Sex | Male | 1.00 (reference) | 1.00 (reference) | ||||||
Female | 1.16 (0.29–4.66) | 0.83 | 1.29 (0.30–5.46) | 0.73 | |||||
PS | 0–1 | 1.00 (reference) | 1.00 (reference) | ||||||
2–4 | 0.79 (0.20–3.16) | 0.74 | 1.42 (0.40–4.97) | 0.59 | |||||
Ann Arbor stage | I–II | 1.00 (reference) | 1.00 (reference) | ||||||
III–IV | 0.61 (0.13–2.98) | 0.55 | 0.47 (0.11–2.01) | 0.31 | |||||
IPI | 0–2 | 1.00 (reference) | 1.00 (reference) | ||||||
3–5 | 0.56 (0.13–2.33) | 0.42 | 1.77 (0.44–7.04) | 0.42 | |||||
BM involvement | N | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||||
Y | 0.61 (0.15–2.44) | 0.48 | 0.25 (0.06–1.03) | 0.06 | 0.35 (0.06–1.93) | 0.23 | |||
Mediastinal lesions | N | 1.00 (reference) | 1.00 (reference) | ||||||
Y | 0.65 (0.17–2.43) | 0.52 | 1.06 (0.26–4.38) | 0.94 | |||||
LDH | ≤ ULN | 1.00 (reference) | 1.00 (reference) | ||||||
> ULN | 0.49 (0.10–2.41) | 0.38 | 0.92 (0.23–3.67) | 0.91 | |||||
Factors at HSCT | |||||||||
Age at HSCT, y | < 35 | 1.00 (reference) | 1.00 (reference) | ||||||
≥ 35 | 0.79 (0.21–2.97) | 0.73 | 0.95 (0.27–3.37) | 0.93 | |||||
HCT-CI | 0 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
1- | 3.43 (0.91–12.9) | 0.07 | 3.48 (0.89–13.65) | 0.07 | 4.53 (1.24–16.5) | 0.02* | 4.80 (0.96–24.1) | 0.06 | |
Disease risk | Standard | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
Advanced | 5.92 (1.22–28.8) | 0.03* | 5.97 (1.21–29.4) | 0.03* | 3.62 (1.02–12.9) | 0.06 | 2.29 (0.66–7.93) | 0.19 | |
Donor source | Auto | 1.00 (reference) | 1.00 (reference) | ||||||
Allo | 1.37 (0.28–6.60) | 0.70 | 0.65 (0.20–2.18) | 0.49 | |||||
Conditioning regimen | MAC | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||||
RIC | 3.23 (0.85–12.2) | 0.09 | 5.00 (1.26–19.6) | 0.02* | 1.76 (0.32–9.82) | 0.52 | |||
Year of HSCT | -2009 | 1.00 (reference) | 1.00 (reference) | ||||||
2010- | 6.11 (0.76–49.2) | 0.09 | 3.20 (0.80–12.7) | 0.10 | |||||
