Figure 7
CEST and rNOE contributions of 22Rv1 and DU145 tumour and necrotic regions with a B1 of 2 μT. Data is shown at offsets of 3.5, 2.0, and − 3.3 ppm. There are consistent significant differences between 22Rv1 tumour and necrotic regions and between DU145 tumour and necrotic regions. The contributions are calculated using the apparent exchange rate (AREX) formula. Similar differences also exist in the comparison with a B1 of 0.5 μT (see Supplementary Fig. S6). The CEST and rNOE contribution calculated using conventional subtraction method have, however, failed to reveal the differences between these cell lines (see Supplementary Fig. S7). ***p < 0.001.
