Figure 2 | Scientific Reports

Figure 2

From: SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stress

Figure 2

Most significantly (Bonferoni-adjusted p < 1E−11) correlated (red to yellow in last column) or anti-correlated (green) genes with ACE2. The transmembrane serine protease 4 (TMPRSS4) is one of the most significantly correlated (r = 0.9142, p = 4.59E−20) with ACE2 suggesting a major role in priming the SARS-CoV2 spike protein. CXCL17 (r = 0.9273, p = 1.1E−21), ABCA12 (r = 0.9256, p = 1−92E−21) and ATP10B (r = 0.9193, p = 1.14E−20) had marginally higher correlation with ACE2 while another transmembrane protease TMPRS11E (r = 0.9121, p = 7.91E−20) had slightly lower correlation.

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