Table 4 Multivariate logistic regression analyses to predict the detection of clinically significant prostate cancer at biopsy in patients with PI-RADS 4/5 lesions.

From: The Prostate Health Index aids multi-parametric MRI in diagnosing significant prostate cancer

Variable

Cutoff

Sensitivity

Specificity

Adjusted ORa (95% CI)

P value

tPSA

6.531

0.843

0.439

7.583 (2.093–27.477)

0.0020

%fPSA

0.142

0.667

0.737

0.194 (0.069–0.551)

0.0021

p2PSA

25.280

0.451

0.789

6.545 (1.967–21.774)

0.0022

%p2PSA

1.502

0.804

0.561

4.821 (1.640–14.170)

0.0042

PHI

48.079

0.745

0.754

11.734 (3.437–40.063)

 < 0.0001

  1. Excluding PSA density in multivariate model to avoid multi-collinearity problems.
  2. PI-RADS, Prostate Imaging Reporting and Data System; PSA, prostate-specific antigen; tPSA, total PSA; fPSA, free PSA; %fPSA, fPSA to tPSA ratio; p2PSA, [-2]pro PSA; %p2PSA, p2PSA to fPSA ratio; PHI, Prostate Health Index; OR, odds ratio; CI, confidence interval.
  3. aAdjusted for age, prostate volume, previous negative biopsy and abnormal digital rectal examination.
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