Table 5 AUC of various PSA derivatives compared to tPSA in patients with PI-RADS 3 lesions.

From: The Prostate Health Index aids multi-parametric MRI in diagnosing significant prostate cancer

 

Total prostate cancer

Clinically significant prostate cancer

AUC (95% CI)

P value

AUC (95% CI)

P value

tPSA

0.544 (0.386–0.702)

 

0.523 (0.352–0.695)

 

PSAD

0.711 (0.573–0.850)

0.0022

0.667 (0.507–0.826)

0.0099

%fPSA

0.607 (0.450–0.765)

0.5076

0.516 (0.345–0.687)

0.0931

p2PSA

0.684 (0.531–0.836)

0.1139

0.804 (0.664–0.944)

0.0019

%p2PSA

0.746 (0.617–0.875)

0.0972

0.828 (0.720–0.937)

0.0080

PHI

0.824 (0.710–0.937)

0.0013

0.884 (0.792–0.976)

 < 0.0001

  1. PI-RADS, Prostate Imaging Reporting and Data System; AUC, area under curve; PSA, prostate-specific antigen; CI, confidence interval; PSAD, PSA density; tPSA, total PSA; fPSA, free PSA; %fPSA, fPSA to tPSA ratio; p2PSA, [-2]pro PSA; %p2PSA, p2PSA to fPSA ratio; PHI, Prostate Health Index.
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