Table 3 Comparison of model fit characteristics overall and stratified by BMI category.

Model^a	Overall		Lean		Overweight		Obese
Model^a	AIC*	AUC	AIC*	AUC	AIC*	AUC	AIC*	AUC
Without clinical covariates
MH	20,240	0.58	4343	0.55	5846	0.56	7038	0.54
MH + LDL-P	20,222	0.59	4343	0.55	5837	0.57	7032	0.55
MH + LP-IR	20,179	0.61	4332	0.59	5831	0.60	7006	0.59
MH + GlycA	20,162	0.63	4315	0.62	5821	0.63	7016	0.60
MH + HMSP	20,051	0.64	4300	0.63	5782	0.65	6952	0.62
MH + BCAA	20,232	0.61	4344	0.57	5846	0.61	7032	0.59
MH + SCDA	20,155	0.62	4329	0.57	5807	0.62	7010	0.59
MH + all plasma biomarkers	19,919	0.69	4269	0.68	5745	0.69	6907	0.67
With clinical covariates*
MH + clinical covariates	19,676	0.75	4241	0.71	5645	0.76	6780	0.75
MH + LDL-P + clinical covariates	19,675	0.75	4243	0.72	5643	0.76	6782	0.75
MH + LP-IR + clinical covariates	19,660	0.75	4239	0.72	5644	0.76	6771	0.75
MH + GlycA + clinical covariates	19,599	0.76	4210	0.74	5619	0.78	6761	0.76
MH + HMSP + clinical covariates	19,561	0.76	4207	0.73	5613	0.77	6728	0.76
MH + BCAA + clinical covariates	19,674	0.75	4241	0.72	5647	0.76	6781	0.75
MH + SCDA + clinical covariates	19,651	0.75	4236	0.72	5630	0.76	6781	0.75
MH + all plasma biomarkers + clinical covariates	19,482	0.77	4180	0.75	5588	0.78	6711	0.77

*AIC analyses were restricted to individuals who had data needed for all models of traditionally defined MH and for all biomarkers (n = 3222).
Clinical covariates include: age, sex, race, LVEF, CAD, family history of CAD, smoking, LDL-C, and creatinine.

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