Figure 5
From: Mesoscopic cortical network reorganization during recovery of optic nerve injury in GCaMP6s mice
Effect of ONC on visual acuity and retinal cell loss. (A) Following the optic nerve injury in the left eye (day 1 -28), there was a significant decrease in visual acuity of the injured eye and a slight increase of visual acuity of the intact eye when compared to the baseline values. (B) Following the optic nerve injury (day 1 -28), there was a significant decrease in depth perception, which induced a decrease in time spent in the shallow end with no significant recovery. (C) The ONC induced a severe loss of retinal ganglion cells (83–90%) both in central (proximal, dark green) and peripheral (distal, light green) regions of the retina. Insert: microphotographs of flat mount retinas stained with RBPMS, showing the 17% survival of the RGC (after bilateral ONC). (*) Indicates Wilcoxon test, between condition (A,C) or between shallow and deep end (B) and which provided p values under 0.05. (#) Indicates Friedman test, between baseline and current day and which provided p values under 0.05. ONC optic nerve crush, OD right eye (oculus dexter), OS left eye (oculus sinister).
