Table 3 Upregulated genes in KF-Tx cells matched in DIANA-miRNAPath pathway analysis.

From: Integrative microRNA and gene expression analysis identifies new epigenetically regulated microRNAs mediating taxane resistance in ovarian cancer

Gene ID

Gene name

Fold change

p-value

AKT2

V-akt murine thymoma viral oncogene homolog 2

3.1a

0.037598

FZD3

Frizzled family receptor 3

2.72

0.000732

CDKN1A

Cyclin-dependent kinase inhibitor 1A

5.68

0.000244

APC

Adenomatous polyposis coli

3.2a

0.000244

LAMC1

Laminin, gamma 1 (formerly LAMB2)

1.6

0.000244

CCND2

Cyclin D2

6

0.000244

GNB5

Guanine nucleotide binding protein (G protein)

1.84

0.000244

PIK3R3

Phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

1.5

0.001953

PVRL1

Poliovirus receptor-related 1

1.68

0.030273

FGF2

Fibroblast growth factor 2

5.2

0.000732

WNT5A

Wingless-type MMTV integration site family, member 5A

3.2

0.000244

PAK1

P21 protein (Cdc42/Rac)-activated kinase 1

1.59

0.000732

CRK

V-crk sarcoma virus CT10 oncogene homolog (avian)

1.53a

0.000732

FADD

Fas (TNFRSF6)-associated via death domain

1.57

0.000244

BCL2L1

BCL2-like 1

1.58

0.000244

IRS1

Insulin receptor substrate 1

1.8

0.000244

PPP2R1B

Protein phosphatase 2, regulatory subunit A, beta

1.6a

0.000244

CFLAR

CASP8 and FADD-like apoptosis regulator

2.21

0.001953

FGFR3

Fibroblast growth factor receptor 3

1.9

0.000244

IFNAR2

Interferon (alpha, beta and omega) receptor 2

2.05

0.000732

CASP8

Caspase 8, apoptosis-related cysteine peptidase

1.83a

0.000732

PLCG2

Phospholipase C, gamma 2 (phosphatidylinositol-specific)

1.72

0.000244

CSNK1E

Casein kinase 1, epsilon

1.76

0.030273

TEAD1

TEA domain family member 1

1.6a

0.000244

E2F2

E2F transcription factor 2

3.34

0.010742

GPC4

Glypican 4

2.7

0.00293

RUNX2

Runt-related transcription factor 2

3.17a

0.023926

RELA

V-relreticuloendotheliosis viral oncogene homolog A

1.77

0.001221

VCL

Vinculin

1.78

0.000244

  1. aIndicate that the indicated expression takes place only when KF-Tx cells were challenged with PTX. However, the other genes’ expression values (without asterisks) indicated changes in their expression in the resistant versus responsive cells without drug challenge.