Table 1 Cytotoxic activity of 1–7 against breast tumor and normal cell lines.

From: Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production

Compound

Cytotoxicity, IC50, μM

Breast cancer cell lines

Normal cell lines

MCF-7

4T1

H9C2

3T3

HEKa

MDCK

A7r5

Na2SeO3

17.1 ± 2.4

4.9 ± 0.6

1.5 ± 0.3

22.3 ± 3.6

13.3 ± 1.1

6.3 ± 0.4

39.4 ± 8.2

Doxorubicin

1.0 ± 0.3

0.16 ± 0.06

11.0 ± 1.0

0.75 ± 0.09

n.t

57.0 ± 6.1

1.82 ± 0.35

1

3.10 ± 0.03

0.30 ± 0.03

1.8 ± 0.1

0.13 ± 0.02

2.31 ± 0.02

3.26 ± 0.40

2.89 ± 0.42

2

0.39 ± 0.03

1.1 ± 0.08

4.2 ± 0.3

1.6 ± 0.3

2.78 ± 0.08

6.27 ± 0.29

1.87 ± 0.26

3

0.50 ± 0.02

0.044 ± 0.005

2.2 ± 0.1

0.39 ± 0.05

2.21 ± 0.02

2.91 ± 0.13

1.85 ± 0.22

4

1.48 ± 0.04

0.45 ± 0.02

2.9 ± 0.1

0.79 ± 0.02

2.05 ± 0.05

2.54 ± 0.57

1.93 ± 0.16

5

0.29 ± 0.01

0.41 ± 0.05

9.3 ± 0.2

0.98 ± 0.03

2.01 ± 0.08

1.51 ± 0.37

1.92 ± 0.44

6

3.23 ± 0.03

1.7 ± 0.2

3.7 ± 0.2

7.4 ± 0.8

2.84 ± 0.08

6.58 ± 0.33

1.97 ± 0.27

7

1.48 ± 0.02

0.94 ± 0.06

0.67 ± 0.02

2.2 ± 0.3

2.19 ± 0.09

4.28 ± 0.34

1.66 ± 0.25

  1. Values are shown as the means ± S.D. from 3 independent experiments.
  2. nt, not tested.
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