Figure 8
From: Impact of tumor-parenchyma biomechanics on liver metastatic progression: a multi-model approach
Colorectal cancer metastasis in human liver: A Hematoxylin and eosin (H&E) stained whole slide image of a CRC metastasis in liver. Note the deformed liver parenchyma (C) near the tumor-parenchyma boundary (dashed line), which indicates sufficient tissue deformation (strain) to be observed macroscopically. Scale bar: 2 mm. B Magnified view of the yellow box from A near the tumor boundary. Note that the regular liver microstructure has been deformed (strained) to be highly anisotropic, indicating compression in the direction orthogonal to the tumor boundary (dashed line) and potential stretching in the direction parallel to the boundary. This deformation is greatest near the tumor (C) and decreases farther from the tumor boundary (C*). The yellow highlighted cells in the inset show tumor cells growing along paths of mechanical least resistance in collapsed sinusoids. Scale bar: 100 \(\upmu \hbox {m}\).
