Figure 1 | Scientific Reports

Figure 1

From: Intra-articular collagenase in the spinal facet joint induces pain, DRG neuron dysregulation and increased MMP-1 absent evidence of joint destruction

Figure 1

Paw withdrawal threshold (PWT) for 21 days after intra-articular injection of collagenase or vehicle. PWTs quantifying mechanically evoked pain-like behavior exhibit a decrease (corresponding to greater sensitivity) after collagenase injection (12 rats) at all days (#p < 0.001) compared to baseline (day 0). Intra-articular injection of vehicle (6 rats) produces a decrease in PWT from baseline (&p = 0.009) at day 1 that resolves by day 3. Starting on day 3, intra-articular collagenase induces sensitivity that is significantly lower (*p ≤ 0.036) than vehicle for all days of testing. All p-values are calculated using a repeated-measures ANOVA and post-hoc Tukey HSD tests; data are expressed as mean ± standard deviation (SD) for each group.

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