Figure 1
From: Spatiotemporal analysis of soluble aggregates and autophagy markers in the R6/2 mouse model
Dynamics of mHTT aggregate formation across different stages of disease progression in R6/2. (A)–(D) Representative blots for the expression of mHTT aggregates in R6/2 compared to wild-type control mice in the Cortex (C), Hippocampus (H), Striatum (S), and Cerebellum (CB) respectively at 2, 4, 8, and 12 weeks. mHTT aggregates were detected by EM48. N = 5 for 2 weeks, N = 7 for 4 and 8 weeks, and N = 12 for 12 weeks. N = number of mice. The genotypes are separated by vertical dashed lines. Image brightness and contrast were adjusted for representative purpose. Blots with different exposures and full uncropped raw blots are represented in the supplementary Figs. S1 and S7, respectively.
