Table 3 Summary of radiomics features for dbPET and wbPET.

From: Evaluation of primary breast cancers using dedicated breast PET and whole-body PET

 

Features

dbPET

Median (IQR)

wbPET

Median (IQR)

Median difference (95% CI)

P-Value

Morphology

Mesh volume (cm3)

6.08 (2.94–13.65)

19.19 (7.36–26.87)

− 11.00 (− 22.59, − 2.13)

0.006

Surface area (cm2)

26.12 (15.46–68.29)

51.59 (25.28–92.57)

− 17.76 (− 150.57, 2.66)

0.77

Sphericity

0.65 (0.54–0.69)

0.70 (0.58–0.74)

− 0.03 (− 3.06, 0.90)

0.43

Maximum 3D Diameter (cm)

4.24 (2.63–4.80)

43.72 (34.37–72.71)

− 1.13 (− 43.07, 0.22)

0.28

Tumor Intensity

Entropy

7.96 (7.49–9.12)

8.89 (8.02–10.33)

− 1.12 (− 2.53, 0.3)

0.28

Uniformity

5.1e−3 (2.1e−3–6.5e−3)

2.4e−3 (9.5e−4–4.6e−3)

6.3e−4 (− 0.003, 0.005)

0.70

Skewness

0.90 (0.83–1.07)

0.59 (0.43–0.76)

0.32 (− 0.11, 0.65)

0.13

Kurtosis

3.31 (2.74–3.62)

2.69 (2.57–3.31)

0.53 (− 0.63, 2.93)

0.19

Standard Deviation

1.42 (0.99–2.09)

1.7 (1.22–2.82)

− 0.60 (− 3.06, 0.90)

0.43

GLCM

Contrast

2.6e4 (1.4e4–7.7e4)

1.9e4 (7.2e3–2e5)

6.8e3 (− 3.6e5, 1.1e5)

0.92

Correlation

0.43 (0.27–0.54)

0.78 (0.76–0.84)

− 0.42 (− 0.60, − 0.25)

0.002

Inverse Difference

0.03 (0.02–0.04)

0.03 (0.01–0.05)

− 0.01 (− 0.11, 0.01)

0.56

Normalized Inverse Difference

0.87 (0.84–0.90)

0.92 (0.90–0.93)

− 0.05 (− 0.08, − 0.02)

0.002

Joint Energy

9.01e−4 (4.5e−4–0.002)

6.5e−4 (2.4e−4–9.7e−4)

5.14e−4 (− 1.86e−5, 8.37e−3)

0.084

Joint Entropy

10.17 (8.93–11.13)

10.97 (10.03–12.06)

− 0.71 (− 2.30, − 0.15)

0.01

NGTDM

Busyness

0.008 (0.003–0.019)

8.2e−4 (2.8e−4–1.4e−3)

0.004 (− 0.04, 0.01)

0.0840

Coarseness

0.003 (0.002–0.007)

0.006 (0.003–0.009)

− 0.002 (− 0.005, 0.007)

0.2324

Complexity

4.6e6 (2e6–3.7e7)

8.7e6 (1.7e6–2.8e8)

− 4.69e6 (− 1.97e9, 5.37e7)

0.7695

Contrast

31.52 (10.06–116.78)

10.8 (8.05–49.11)

42.24 (− 26.82, 242.48)

0.2754

Strength

490.9 (248.9–1.6e3)

2.4e3 (1.4e3–6.6e3)

− 0.001 (− 1.4e4, 176.6)

0.1602

  1. Statistical significance, median difference, and 95% confidence intervals were assessed using the Wilcoxon signed-rank test.
  2. GLCM gray-level co-occurrence matrix, NGTDM neighborhood gray-tone difference matrix.