Figure 2

Sample Clustering and PCA analysis based on CD4⁺ cell transcriptomic data. The hierarchical clustering in heatmaps and 2D PCA plots with ellipses concentration clearly show separation of the responder and non-responders. In the heatmaps, columns are samples and rows are differentially expressed genes, the expression levels are presented as median-centered. Samples in the red-dashed lines were non-responders and samples in the blue-dashed lines were responders. (a) and (b) are heatmap and PCA plot for IL17i responder and non-responders; (c) and (d) are heatmap and PCA plot for TNFi responder and non-responders.