Table 3 Drug levels of rexinoids and cholesterol and triglyceride levels in the plasma of A/J mice.

From: The novel rexinoid MSU-42011 is effective for the treatment of preclinical Kras-driven lung cancer

 

Control

Bexarotene

MSU 42011

Drug levels (nM)

None

81.2 ± 14.9

97.4 ± 13.3

Cholesterol (µg/µL)

1.26 ± 0.07

1.99 ± 0.1ǂ

1.4 ± 0.05*

Triglycerides (nmol/µL)

1.32 ± 0.12

2.21 ± 0.16ǂ

1.39 ± 0.11*

  1. Female A/J mice were fed rexinoids (100 mg/kg diet) or control diet for 12 weeks. Steady state drug levels in plasma were determined by liquid chromatography-mass spectrometry. Cholesterol and triglycerides levels were quantified using commercially available kits as described in the Methods. n = 8 mice/group. ǂ, p < 0.01 vs. control; *, = p < 0.01 vs. bexarotene. Results shown are mean ± SE.
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