Figure 3 | Scientific Reports

Figure 3

From: (−)-Gallocatechin gallate from green tea rescues cognitive impairment through restoring hippocampal silent synapses in post-menopausal depression

Figure 3

Silent synapses are re-emerged following HTP-GTE administration in OVX rats. (a-d) Representative traces for EPSCs evoked by minimal stimulation for 50 trials at holding potentials of -70 mV or + 40 mV in the slices from sham-OVX resilient + vehicle, OVX helpless + vehicle, OVX + HTP-GTE 200 mg/kg, and OVX + HTP-GTE 400 mg/kg groups. (e–h) Time course of EPSC amplitudes in representative cells shown in collected -70 mV (blue symbols) and + 40 mV (red symbols). (i–l) Failure rates for EPSCs at − 70 mV or + 40 mV in slices for all groups. (m) Percentage of silent synapse proportions for all groups (Sham-OVX resilient + vehicle: 33.19 \(\pm \) 3.38, n = 7; OVX helpless + vehicle: 3.925 \(\pm \) 3.89, n = 6; OVX + HTP-GTE 200 mg/kg: 28.78 \(\pm \) 2.82, n = 7; OVX + HTP-GTE 400 mg/kg: 26.63 \(\pm \) 2.67, n = 6).

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