Figure 3 | Scientific Reports

Figure 3

From: Continuous monitoring of neutrophils to lymphocytes ratio for estimating the onset, severity, and subsequent prognosis of immune related adverse events

Figure 3

NLR trends in patients with endocrine irAEs. (a) Plotting the NLR trends during the 100 d before the development of ICI-related thyroiditis (n = 17) and hypophysitis (n = 12). The gray line indicates the individual patients, and the red line shows the mean ± SEM. (b) NLR elevation from the baseline was analyzed at each time point in thyroiditis, and (c) hypophysitis. (d) Pre-treatment NLR (baseline) was compared among patients who experienced endocrine irAEs (n = 26) and all other patients in our dataset (n = 248). Statistical analysis included one-way ANOVA with a mixed-effects model followed by Holm–Sidak’s post hoc test (b), one-way ANOVA with Tukey’s post hoc test (c), and Mann–Whitney test (d). Data are shown as the mean ± SEM (b, c), and the median in (d), *p < 0.05. NLR neutrophil-to-lymphocyte ratio, ICI immune checkpoint inhibitor, irAE immune-related adverse event.

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