Figure 4 | Scientific Reports

Figure 4

From: NT-PGC-1α deficiency attenuates high-fat diet-induced obesity by modulating food intake, fecal fat excretion and intestinal fat absorption

Figure 4

NT-PGC-1α ablation reduces HFD-induced adipocyte hypertrophy and inflammation. (A) Weights of tissues collected from female WT and NT-PGC-1α−/− mice fed HFD for 16 weeks (n = 12 per group). (B) Triglyceride content of livers from female WT and NT-PGC-1α−/− mice fed HFD (n = 10 per group). (C) Representative images of H&E-stained sections of adipose tissues and livers from female WT and NT-PGC-1α−/− mice fed HFD. Images were viewed through the NDP.view 2 software (https://www.hamamatsu.com/us/en/product/type/U12388-01/index.html). Magnification ×16.1 (BAT), ×5 (iWAT, gWAT), and ×10 (liver). (D, E) Quantitative real time PCR analysis of genes involved in inflammation in inguinal and gonadal adipose tissue from WT and FL-PGC-1α−/− female mice fed HFD (n = 10–12 per group). All data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 determined by Student’s t test.

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