Figure 7
From: OpenEP: an open-source simulator for electroporation-based tumor treatments

Examples of IRE and Different H-FIRE Pulse Waveforms: (a) IRE treatments deliver a series of long-duration monopolar pulses. (b) H-FIRE treatments typically deliver multiple bursts containing \(0.25\, \upmu \hbox {s}\) and \(5\, \upmu \hbox {s}\) alternating polarity pulses. Example waveforms showing the first \(10 \, \upmu \hbox {s}\) of a (c) \(2 \, \upmu \hbox {s}\) monopolar, (d) asymmetric \(2\, \upmu \hbox {s}\), \(1\, \upmu \hbox {s}\) and \(0.25\, \upmu \hbox {s}\) (positive–delay–negative), and (e) symmetric \(2\, \upmu \hbox {s}\), \(1\, \upmu \hbox {s}\) and \(2\, \upmu \hbox {s}\) (positive–delay–negative) H-FIRE bursts. Figure reproduced from Sano et al.27.